We want to empower people to deal with their malignant cells through their own immune system just like we deal with viral infections. Today’s cancer immunotherapies are powerful but, to the detriment of their effect, not very tumor-selective.
Contrary to the classical cell surface targets, there is a reservoir of highly tumor-specific proteins inside the cancer cells. CDR-Life has developed a technology to make MHC-specific antibodies that target these highly tumor-specific intracellular antigens. Combined with our proprietary modular multispecific format, this enables us to develop tumor-selective & drug-like T cell engagers.
With access to a reservoir of unexploited intracellular cancer targets, we are advancing a growing pipeline of highly tumor-selective immunotherapies.
The CDR-Life team covers all areas of expertise in biologics drug development from discovery to technical development and has experience through all phases of development – from early phase to Biologics licensing application (BLA) submission.
We have in-house groups with deep expertise covering antibody discovery, pharmacology, developability, Drug Substance, and Drug Product & Analytics, enabling us to break new ground in with our versatile and drug-like therapeutic antibodies.
CDR-Life is lead by the team behind ESBATech and Beovu®. It is a team of inventors, drug developers, and biotech builders with a uniquely proven track record.
Christian is a seasoned drug developer. He has worked in all phases of drug development within the areas of ophthalmology, oncology, autoimmunity, cardiovascular disease. Christian has led several global programs with new biologic entities including LME636 (Novartis) from the preclinical stage up through successful Phase 2 in two different ophthalmic diseases. He has also played lead roles in the clinical development of Rydapt (Approved in rare hematological disease) and brolucizumab (positive Phase 3 in retinal disease).
Christian has served in Business Development & Licensing teams in Alcon and Novartis and was part of the senior management in ESBATech.
He obtained his Ph.D. in biochemistry from ETH Zurich, Switzerland. In addition, he holds a Master of Science in Molecular Biology and in Chemistry from Roskilde University, Denmark.
Leonardo is an accomplished protein engineer with a track record in preclinical development of antibodies. After joining ESBATech in 2004, he designed and optimized numerous scFvs including brolucizumab (RTH258), which recently achieved positive Phase III against wet AMD in Novartis and is now being prepared for approval and launch.
In his role as Head of Protein Engineering at ESBATech, Leonardo was responsible for leveraging the scFv platform for the generation of bispecific antibodies, directed strategies to assess manufacturing properties and risks of antibody fragments, and led multiple projects from antibody discovery to early development for Alcon and later for Novartis.
More recently Leonardo led the scaffold technologies group at Novartis Biologics Center where he continued his work in antibody based scaffolds and multispecifics for different disease areas including immuno-oncology, cardiovascular diseases, and ophthalmology.
Leonardo developed a generically applicable antibody humanization procedure that for the first time resulted in highly stable and potent antibody fragments. He is inventor on numerous patents and his scientific work has been published in peer-reviewed journals.
Leonardo is heading the Research Unit in CDR-Life.
Konstantin von Schulthess’ experience stretches over more than 15 years in financial leadership roles. He looks back on 9 years in R&D finance – first as global controller at Hoffmann-La Roche and then as CFO at ESBATech. He is the founder and owner of Goldhalden, a consultancy focusing on leadership in finance roles.
At ESBATech, Konstantin oversaw all financial and business activities including funding, investor relations, budgeting, reporting, IT and infrastructure. Together with Dominik Escher he took part in the transaction team during the USD 589 million trade sale of the company to Alcon in 2009.
Prior to joining ESBATech Konstantin was the first global life-cycle controller at Roche. Building up this new role, he managed a total R&D and marketing budget of more than USD 400 million for Roche’s Anti-CD 20 (Rituximab / Ocrelizumab / Obinutuzumab).
Konstantin holds a law degree of the University of St.Gallen and an MBA from Babson College, Massachusetts (summa cum laude). He is a Swiss Certified Accountant. Konstantin is also a board member at Schulthess Klinik, Uznaberg AG, and Goldhalden.
Rouven is an accomplished leader in technical development and manufacturing of biologics. He was Head of Downstream Processing & Analytics in ESBATech and Novartis (>6 years) and subsequently worked as Global Drug Substance Lead in Novartis.
Rouven played leading roles in successful development of manufacturing processes for multiple therapeutic antibody formats including antibody fragments, multi-specific antibodies, and monoclonal antibodies via both microbial and mammalian processes. In addition, he was part of the team that prepared the IMPD and BLA submissions for brolucizumab (Novartis).
Rouven is heading the Technical Development Unit in CDR-Life.
Dominik is a biotechnology entrepreneur. He was a founder of ESBATech and was leading the company as CEO since its inception in 1998 until 2016. He raised more than USD 90 million venture capital for ESBATech AG. In 2009, ESBATech AG was acquired for USD 589 million by Alcon.
Within Alcon Dominik continued to lead ESBATech and was Vice President of R&D Alcon and member of the group’s Global R&D Leadership Team.
In 2011, when Alcon was acquired by Novartis, ESBATech joined the Novartis Institutes of Biomedical Research (NIBR). As Head of ESBATech, a Novartis company, Dominik was a member of the NIBR Global Ophthalmology Leadership Team as well as the NIBR Global Leadership Team of Biologics.
At the same time as ESBATech AG was sold to Alcon, Dominik was a founder of Delenex Therapeutics. He served on the board of this new biotech company until it was acquired by Cell Medica in 2016.
Dominik obtained his Ph.D. from the University of Zurich. He also holds a Master of Science in Molecular Biology and Immunology from the University of Zurich and a Masters Degree in Education with specialization in Management and Organization from the ETH of Zurich.
Since 2002 he is a Board Member of the Swiss Biotech Association, the biotech industry organization of Switzerland which he leads as President since 2013.
The Scientific Advisory Board consists of experts within the fields of immunooncology and ophthalmology and will serve as a vital strategic resource to the company to develop novel and impactful medicines.
In addition to guiding CDR-Life’s research and development activities, including clinical trial designs, the SAB will also identify new target indications and will evaluate strategic assets that leverage the management’s expertise in therapeutic antibody fragments.
Dr. Jaeger is Professor in Hematology at the Medical University of Vienna and Head of the Hematology and Hemostaseology Department at Vienna General Hospital (AKH Wien). During his training, he completed a three-year research stay with Prof. Stanley Korsmeyer at Washington University in St. Louis. His clinical and scientific focus is on lymphoproliferative diseases (leukemia and lymphoma). As a study director, he is responsible for the international NHL13 study of aggressive lymphoma and for acute lymphocytic leukemia of the adult age within the Study Group of Medical Tumor Therapy (AGMT). He is also lead investigator in several Austrian and international studies. His special focus is on translational research. Dr. Jäger was President of the European Hematology Association (EHA) from June 2011 to June 2013 and is currently a member of the European Biomed Alliance and the European Alliance for Personalized Medicine.
Dr. Manz is Professor in Hematology at the University of Zurich. He is the Director of Hematology at the University Hospital of Zurich where he also serves as the Director of Center for Hemato-Oncology. In addition, he is the Head of the Leukemia, Lymphoma, and Myeloma Center at the Comprehensive Cancer Center Zurich (CCCZ).
Joshua Richter, MD, is Assistant Professor of Medicine in The Tisch Cancer Institute, Division of Hematology and Medical Oncology, Mount Sinai. Dr. Richter treats patients with plasma cell dyscrasias, including multiple myeloma and related diseases such as amyloidosis and Waldenstrom’s Macroglobulinemia. Dr. Richter has extensive experience with clinical trials focused on novel therapies, including antibody therapy and immunotherapy for a precision medicine approach. In addition, he has published in numerous reputable oncology journals including Blood, Journal of Clinical Oncology, and the British Journal of Haematology.
Dr. Holz is a leading researcher in age-related macular degeneration (AMD) and related imaging technologies. He has also been involved in several high profile clinical trials with innovative therapies for macular disease, and has contributed significant advances in the understanding of AMD phenotypes as well as macular telangiectasia, including characterizing the natural history in many patients and identifying early markers of the disease. For the last three decades, Dr. Holz has been at the forefront of clinical research using the most advanced retinal imaging modalities. He is one of the early adopters of confocal scanning laser ophthalmoscopy based fundus autofluorescence imaging as well as OCT-angiography. He founded the GRADE Reading Center Bonn to perform digital image analysis in multicentre clinical natural history and interventional trials. Dr. Holz serves as Editor-in-Chief of the journal of the German Ophthalmological Society (DOG), Der Ophthalmologe, is a past president of DOG, and Board member of Euretina. He has received numerous awards including the Pro Retina Macular Degeneration Research Award, the Leonhard-Klein Award for Ocular Surgery, the Alcon Research Institute (ARI) Award, the Senior Achievement Award of the AAO and the Jules Gonin Award. He published more than 400 articles in peer-reviewed journals and is editor of several books on retinal diseases.
Professor at the University of Zurich and Vice Chair at City Hospital Triemli, Zurich, Switzerland Dr. Michels currently serves as vice-chair and head of medical retina at the Department of Ophthalmology, City Hospital Triemli, as well as professor at the University of Zurich. He obtained his ophthalmology training at the University of Luebeck, Emory University in Atlanta, the Bascom Palmer Eye Institute in Miami and the Medical University of Vienna. Dr. Michels was the first to study the potential use of bevacizumab (Avastin®) and canakinumab (Ilaris®) in ophthalmology and is known for his work on therapeutic treatment strategies (PrONTO-Study). He has published more than 80 peer-reviewed articles and has acted as principal or co-investigator in more than 25 clinical trials. He is leading the largest single intravitreal injection center in Switzerland and one of the leading centers for clinical studies on macular diseases in Switzerland.
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