Careers

Working at CDR-Life

CDR-Life is developing tumor-targeted immunotherapies to address unsolved problems in oncology by applying our LocATE antibody technology. To achieve our ambitious goals, we have created a dynamic working environment where we value curiosity, innovative thinking, committed teamwork, and the motivation to make an impact. We believe in trust and openness when doing our jobs, which may at times, take us beyond our comfort zones.

CDR-Life is a young biotech company giving our employees the opportunity to grow in their roles and have a direct impact on the development of novel therapies for people in urgent need. We are building a highly diverse team that collaborates across functions with a strong project focus and a flat hierarchy.

Open Positions

Technical Scientist Small Scale Production (100%)

Production of antibody fragments to discover new first-in-class immuno-oncology drugs

You will play an important role in the production of antibodies and antibody-derived molecules in mammalian cell lines and collaborate with colleagues to deliver first-in-class biologics. In addition, you will help to drive innovative approaches for drug discovery using novel antibody and protein engineering technologies. We are looking for a highly motivated and collaborative individual with a passion for drug discovery research, who enjoys working in a fast-paced and highly dynamic working environment.

Responsibilities:

  • Perform transient transfection in mammalian cell cultures.
  • Execute various purification methods using state of the art Aekta systems.
  • Perform basic analytical methods such as SDS PAGE and SE-HPLC.
  • Support/perform production of animal trial material with low endotoxin levels.
  • Plan and execute plasmid cloning and DNA purification activities.
  • Ensure best practices of research, data management, and archiving.
  • Proactively prepare and/or organize required equipment, consumables, and reagents.

Your Profile:

  • Apprenticeship, BS, MSc. or equivalent in biology, biochemistry or a related discipline.
  • Demonstrated expertise in protein purification is essential.
  • Experience in mammalian cell culture techniques is essential.
  • Experience in basic analytical methods such as SE-HPLC and SDS PAGE.
  • Experience in basic molecular biology techniques.
  • Experience in endotoxin free protein production would be a plus.
  • Ability to work independently in a team environment.
  • Positive and proactive attitude.

Interested? Please send your documents to thomas.schleier@cdr-life.com. We look forward to receiving your application.

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Technical Scientist for Screening (100%)

Identification of new antibody fragments to generate first-in-class immuno-oncology drugs

You will play an important role in the screening and hit identification of antibodies and antibody-derived molecules while collaborating with colleagues to deliver first-in-class biologics. In addition, you will help to drive innovative approaches for drug discovery using novel antibody and protein engineering technologies. We are looking for a highly motivated and collaborative individual with a passion for drug discovery research, who enjoys working in a fast-paced and highly dynamic working environment.

Responsibilities:

  • Execute/support antibody screening campaigns.
  • Perform phage display antibody library generation and selection.
  • Perform FACS-based cell sorting.
  • Perform ELISA-based binding characterization assays.
  • Plan and execute molecular cloning activities.
  • Support recombinant protein production.
  • Support activities for the design and optimization of antibody candidates.
  • Ensure best practices of research, data management and archiving.
  • Proactively prepare and/or organize required equipment, consumables and reagents.

Your Profile:

  • Apprenticeship, BS, MSc. or equivalent in biology, biochemistry, or a related discipline.
  • Demonstrated expertise in molecular biology techniques is essential.
  • Experience with antibody display techniques (phage, yeast or others).
  • Experience with ELISA assay.
  • Experience in FACS sorting would be a plus.
  • Experience in the pharmaceutical industry with focus on antibody screening and/or protein engineering is a plus.
  • Experience with antibody affinity maturation and antibody humanization would be a plus.
  • Experience in recombinant protein production using mammalian cells would be a plus.
  • Ability to work independently in a team environment.
  • Positive and proactive mindset.

Interested? Please send your documents to severin.wendelspiess@cdr-life.com. We look forward to receiving your application.

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Technical Scientist Immuno-Oncology (100%)

In vitro characterization of first-in-class immuno-oncology drugs

We are seeking a passionate and experienced associate as part of the pharmacology team to support CDR-Life’s pipeline of immunotherapies. A central part of the role is the profiling of drug compounds in various cell biological assays. The candidate will work in a matrix environment to drive scientific innovation collaboratively with other members of the pharmacology & discovery group, as well as with other functions including the developability profiling group, CMC unit and external collaborators.

Responsibilities

  • Develop, design, conduct and analyze pharmacological assays for identification, characterization, and validation of immune-based therapies (e. g. proliferation, cytotoxicity, and cytokine release assays).
  • Establish and optimize flow cytometric assays for immunophenotyping and characterization of antibody fragments.
  • Maintain and optimize mammalian cell culture processes and organize and conduct PBMC isolation from buffy coats.
  • Organize and maintain general laboratory infrastructure.
  • Contribute to implementation of immunology/oncology in vitro studies and ex vivo mechanism of action studies.

Qualifications

  • Apprenticeship/B.Sc./M.Sc. with research experience in the fields of cellular biology, immunology and/or cancer immunotherapy, 5+ years industry experience.
  • Highly experienced in mammalian cell culture work, conducting cell-based assays and analysis of multiple immune endpoints (cytotoxicity, proliferation, cytokine levels).
  • Experience in working with primary cells or iPS cells.
  • Hands-on experience with flow cytometry or multiplex assays (Luminex or MSD) is required.
  • Experience with evaluating and implementing new technologies is a plus.
  • Well-organized with an independent and accurate working style (experience with ELN is a plus)
  • Positive, reliable, open-minded, and flexible team player
  • Fluency in English

We are looking forward to receiving your application under melissa.vrohlings@cdr-life.com.

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