A central part of the role is the development, execution, and data analysis of in vitro potency assays (LDH, CTG, Incucyte, ELISA) to support the selection and characterization of clinical candidates. The successful applicant will work in a matrix environment to drive scientific innovation collaboratively with other members of the Pharmacology & Discovery group, as well as with other functions including the Developability profiling group, CMC unit and external collaborators.
Key Responsibilities
- Develop, optimize and conduct cell-based assays focused on the characterization of T cell engagers
– T-cell proliferation/activation
– Cytotoxicity and cytokine induction (LDH, CTG, Incucyte) - Execute routine immunological, molecular, and cellular assays
- Perform ELISAs, cell-based assays, rt-PCR, and isolation of nucleic acids
- Independently analyze and present results to a diverse scientific audience
- Maintain and optimize mammalian cell culture processes
- Analyze experiments using a multicolour flow cytometry
Your Profile
- Laboratory Technician/B.Sc./M.Sc. with research experience in the fields of immunology and/or cancer immunotherapy, 3-5+ years industry experience
- Required previous experience in conducting cell-based assays and analysis of multiple immune endpoints (cytotoxicity, proliferation, cytokine levels)
- Experience with 384 wells co-culture assay setups preferred
- Experience with flow cytometry
- Use of analysis software GraphPad Prism
- Well-organized with an independent and accurate working style, ability to handle multiple tasks in parallel
- Excellent communication skills
- Positive, reliable, open-minded, and flexible team player
- Fluency in English
Are you interested? For any further questions or your application please contact: alessio.vantellini@cdr-life.com. We are looking forward to hearing from you.