Posters
AACR Annual Meeting 2026
Mechanistic insights into the pharmacology of CDR609 support high potential
as a targeted immunotherapy
CONTRIBUTORS:
Athanasia Dasargyri, Alessio Vantellini, André Fonseca, Anna Howald, Blaz Pavlovic, Alice Langer, Martina Priola, Nora Wettstein, Zoi Barou, Cedric Kiss, Hannes Merten,
Sophie Barsin, Stephanie Jungmichel, Leonardo Borras
ESMO Immuno-Oncology Congress 2025
First-in-human evaluation of CDR404, a MAGE-A4–targeted T cell engager, in ovarian cancer: pharmacodynamic and clinical activity findings from early dose cohorts
CONTRIBUTORS:
Kristoffer Rohrberg, Matteo Morotti, Giuseppe Curigliano, Rom Leidner, Mark Diamond, Nikolina Vachtsevanou, Christian Leisner, Sarah Holland, Leonardo Borras, Daniel Lenherr-Frey, Melissa Vrohlings, Swethajit Biswas
AACR-NCI-EORTC 2025
Hallmarks of pharmacodynamic activity of CDR404, a new antibody-derived T cell engager
CONTRIBUTORS:
Melissa Vrohlings, Matteo Morotti, Daniel Lenherr – Frey, Nikolina Vachtsevanou, Clare Price, Leonardo Borras, Rouven Bingel – Erlenmeyer, Paul Swiecicki, Coral Olazagasti, Rom Leidner, Mark Diamond, Kristoffer Rohrberg, Sylvie Rottey, Hans Prenen, Jean – Pascal H Machiels, Nuria Kotecki, Alberto Hernando Calvo, Guillermo de Velasco, Guillermo Suay Montagud, Roda Perez Desamparados, Juan Jesús Martin, Matteo Simonelli, Curigliano Giuseppe, Christian Leisner, Swethajit Biswas, Emiliano Calvo Aller
AACR-NCI-EORTC 2025
CDR609: A First-in-Class LGR5-targeted T Cell Engager for Treatment of Colorectal
Cancer and Other Solid Tumors
CONTRIBUTORS:
Athanasia Dasargyri, Sophie Barsin, Fabian Scheifele, Philipp Richle, Nagjie Alijaj, Anna Sobieraj, Romina Doerig, Hannes Merten, Philip Knobel, Martina Priola , Blaz Pavlovic, Marko Keric, David Schurter, Cedric Kiss, Ariadna Vilarrasa, Stephanie Jungmichel, Matteo Morotti, Swethajit Biswas, Christian Leisner, Leonardo Borras
AACR Annual Meeting 2025
A novel T cell engager antibody for the treatment of HLA-A*01/KK-LC-1-positive tumors
CONTRIBUTORS:
Athanasia Dasargyri, Melissa Vrohlings, Stephanie Jungmichel, Blaz Pavlovic, Martina Priola, Zoi Barou, Hannes Merten, Philip Knobel, Luca Scheu, Romina Dörig, Fabian Scheifele, Philipp Richle, Daniel Kuhn, Gonzalo Acuña, Matteo Morotti
AACR Annual Meeting 2025
Durable and potent in vitro T cell activity with repeated exposure to CDR404; a potential best-in-class T cell engager targeting MAGE-A4
CONTRIBUTORS:
Alessio Vantellini, Nora Wettstein, Melissa Vrohlings, Stephanie Jungmichel, André Fonseca, Alice Langer, Anna Howald, Zoi Barou, Daniel Lenherr-Frey, Matteo Morotti, Christian Leisner, Swethajit Biswas, Leonardo Borras
SITC 2024
First-in-human study of CDR404, a novel bivalent and bispecific, antibody-derived, T cell engager in MAGE-A4-positive advanced solid cancers
CONTRIBUTORS:
Spanggaard I, Morotti M, Swiecicki PL, Simonelli M, Rottey S, Suay G, de Velasco G, Martin-Liberal J, Hernando-Calvo A, Roda D, Kotecki N, Vachtsevanou N, Vrohlings M, Price C, Lenherr-Frey D, Leisner C, Borras L, Bingel-Erlenmeyer R, Biswas S, Prenen H, Curigliano G, Machiels JP, Lopes G, Diamond M, Leidner R, Calvo E
ESMO Congress 2024
Highly potent and specific bivalent T cell engager (TCE) targeting PRAME on HLA-A*02:01
CONTRIBUTORS:
Athanasia Dasargyri, Stephanie Jungmichel, Nagjie Alijaj, Anna Sobieraj, Fabian Scheifele, Philip Knobel, Philipp Richle, Hannes Merten, Romina Doerig, Anna-Maria Evangelopoulou, Martina Priola, Blaz Pavlovic, Ariadna Vilarrasa, Thomas Schleier, Laure-Anne Bickel, Gonzalo Acuña, Swethajit Biswas, Tim Fugmann, Christian Leisner, Leonardo Borras
AACR Annual Meeting 2024
Novel antibodies against a KK-LC-1-derived peptide presented on HLA-A*01 on tumor cells
CONTRIBUTORS:
Fabian Scheifele, Stephanie Jungmichel, Nagjie Alijaj, Anna Sobieraj, Thomas Schleier, Alessio Vantellini, Athanasia Dasargyri, Philip Knobel, Philipp Richle, Hannes Merten, Romina Doerig, Melissa Vrohlings, Swethajit Biswas, Tim Fugmann, Rom Leidner and Leonardo Borras
SITC 2023
Overcoming the dose-response prediction limitation from bench to clinic for T-cell engagers: Using Quantitative Systems Pharmacology (QSP) modeling in the development of CDR404 for solid tumors
CONTRIBUTORS:
Melissa Vrohlings, Drew Marquis, Scott Gruver, Fei Hua, Stephanie Jungmichel, Nadia Sanchez, Alessio Vantellini, Ivana Tosevski, Leonardo Borras and Swethajit Biswas
SITC 2023
CDR404, an antibody-based bispecific & bivalent T-cell engager targeted against MAGE-A4, for Squamous Non-Small Cell Lung Cancer (SQ-NSCLC)
CONTRIBUTORS:
Melissa Vrohlings, Stephanie Jungmichel, Ivana Tosevski, Alessio Vantellini, Philip Knobel, Nadia Sanchez, Elizabeth Ross, Marian Van Kerckhoven, Giorgia Giacomazzi, Maria Liivrand, Reija Hieta, Nicholas Dupuis, Dieter Rondas, Pamela Swatkowski, Daniel Lenherr-Frey, Swethajit Biswas, Gilberto Lopes and Leonardo Borras
ESMO Congress 2023
Precise Tumor & Patient Selection for CDR404: A Bispecific & Bivalent MAGE-A4 T-Cell Engager
CONTRIBUTORS:
G. Giacomazzi, M. Liivrand, R. Hieta, N. Dupuis, D. Rondas, P. Swatkowski, M. Vrohlings, D.Lenherr-Frey, L. Borras, S. Biswas, R. Leidner, E. Calvo
AACR Annual Meeting 2022
Enhanced anti-tumor responses with a novel dual pMHC T-cell engager bispecific antibody
CONTRIBUTORS:
Stephanie Jungmichel, Fabian Scheifele, Anna Sobieraj, Severin Wendelspiess, Thomas Schleier, Philip A. Knobel, Camilla Winnewisser, Zoi Barou, Melissa Vrohlings, Philipp Richle, Hannes Merten, Jacqueline Blunschi, Christian Leisner and Leonardo Borras
AACR Annual Meeting 2021
A powerful discovery platform for the generation of high affinity and specificity TCR-like antibodies for immunotherapies in solid tumor
CONTRIBUTORS:
Stephanie Jungmichel, Fabian Scheifele, Anna Sobieraj, Philip A. Knobel, Philipp Richle, Hannes Merten, Thomas Schleier, Melissa Vrohlings, Camilla Winnewisser, Christian Leisner, and Leonardo Borras
ASH 2021
Preclinical assessment of CDR101 – a BCMAxCD3xPD-L1 trispecific antibody with superior anti-tumor efficacy
CONTRIBUTORS:
Melissa Vrohlings, Jan Müller, Stephanie Jungmichel, David Senn, Anna B. Howald, Thomas Schleier, Fabian Scheifele, Severin Wendelspiess, Philipp Richle, Hannes Merten, Daniel
Lenherr-Frey, Christian Leisner, Markus G. Manz, Leonardo J. Borras