Boehringer Ingelheim Collaborates with CDR-Life to Develop Antibody Fragment-based Therapeutics For Geographic Atrophy, a Leading Cause of Blindness Worldwide

May 13, 2020

The collaboration with CDR-Life is the second strategic partnership within a year for Boehringer Ingelheim in retinal diseases, furthering the company’s commitment to develop novel treatments and technologies for patients who have only inadequate treatment options

Together the partners will advance CDR-Life’s preclinical antibody fragments targeting a key pathway in geographic atrophy (GA)

Ingelheim, Germany and Schlieren, Switzerland – 13 May 2020 – Boehringer Ingelheim and CDR-Life today announced they have entered into a collaboration and licensing agreement to research and develop antibody fragment-based therapeutics for geographic atrophy (GA). GA is a progressive, irreversible retinal disease that occurs in patients with age-related macular degeneration (AMD) for which there is no current treatment. Together, with Boehringer Ingelheim’s expertise in the therapeutic development of biologics and CDR-Life’s strong know-how in antibody engineering, the two companies will progress CDR-Life’s preclinical candidate, with the aim to preserve sight for patients with GA.

“Partnering with CDR-Life provides Boehringer Ingelheim with the opportunity to collaborate with a team that has a proven track record developing antibody fragment-based therapeutics for retinal diseases,” said Clive R. Wood, Ph.D., Corporate Senior Vice President and Global Head of Discovery Research at Boehringer Ingelheim. “The prospect of losing one’s sight is frightening. We are committed to transformational therapies that have the potential to succeed in preserving the health and vision of patients with retinal diseases such as geographic atrophy”

Utilizing antibody fragment-based technology, which retains the specificity of an antibody while significantly reducing the size of the molecule, may have significant advantages over traditional large molecule approaches for the treatment of retinal diseases, such as GA. When applied to the eye via intravitreal injection, high affinity antibody fragment therapies have the potential to reach the retinal pigment epithelial cells where degeneration is known to occur. This precise technology may help decrease the cellular stresses caused by AMD and prevent further loss of sight.

“Boehringer Ingelheim is one of the leading research and development companies in the field of biologics,” said Christian Leisner, Ph.D., Chief Executive Officer at CDR-Life. “This is an exciting partnership that brings together Boehringer Ingelheim’s development expertise and CDR-Life’s innovative antibody fragments to provide hope for people living with a blinding retinal disease. We look forward to advancing this project towards the clinic together with the Boehringer Ingelheim team.”

Boehringer Ingelheim takes a holistic approach to the development of novel retinal disease therapies, targeting key mechanisms in the pathogenesis of retinal diseases. By leveraging existing expertise in oncology, inflammation, neurodegeneration, fibrosis and cardiometabolic diseases, the company has built a comprehensive portfolio of next generation retinal therapy approaches in various stages of development up to Phase 2 in macular degeneration and diabetic retinal diseases.

CDR-Life´s preclinical program utilizing antibody fragment-based technology complements this growing portfolio, providing an innovative approach to treat GA.

Under the terms of the agreement, Boehringer Ingelheim will receive an exclusive, worldwide license to develop certain compounds based on CDR-Life´s technology against a specific target and will be responsible for global development and commercialization. CDR-Life will be eligible to receive up to CHF 474.5 million in upfront and success-based milestone payments, as well as research funding and royalties on sales.

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CDR-Life moves into larger facilities in the Bio-Technopark, Schlieren

January 30, 2020

ZURICH, Switzerland, January 30, 2020 – CDR-Life inc. has moved into new fully equipped laboratory facilities in Wagistrasse 27, 8952 Schlieren-Zurich. This move positions the company to grow and to advance its promising pipeline of game-changing oncology and ophthalmology therapies into clinical trials over the coming years.

CDR-Life Enters Research Collaboration with University Hospital Zurich

October 28, 2019

Ex vivo studies for the prediction of clinical response in multiple myeloma.

ZURICH, Switzerland, October 28, 2019 – CDR-Life inc. has entered a research collaboration with Prof. Markus G. Manz, MD, Head of Medical Oncology and Hematology at University Hospital and University of Zurich, to further test CDR-Life’s trispecific antibodies on primary cancer patient tissue.

The collaboration will combine strong clinical know-how and patient sample access at the University Hospital with CDR-Life’s deep expertise in developing unconventional antibody- based therapies.

“CDR-Life’s trispecific LocATE antibodies are potentially transformative in the field of immunotherapies,” said Prof. Manz. “We are looking forward to help validate the promise of this novel approach.”

“Patient ex vivo testing has been shown to be highly predictive of clinical outcome” said Leonardo Borras, Chief Science Officer at CDR-Life. “Access to world-class expertise and real patient samples for testing our novel antibodies is very powerful.”

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CDR-Life Presents Results at ASCO

June 3, 2019

Local activator and T cell engager (LocATE) selectively blocks PD-L1 at the cytolytic synapse for deeper responses in multiple myeloma.

Poster Abstract

CDR-Life Enters Research Collaboration with ETH Zürich

May 23, 2018

Ex vivo drug response profiling of novel immunotherapies in patient biopsies.

ZURICH, Switzerland, May 23, 2018 – CDR-Life inc. has entered a research collaboration with Prof. Berend Snijder, ETH Zürich, to study the effect of their novel trispecific T cell engagers on cancer patient samples using pharmacoscopy, a human ex vivodrug screening technology.

The collaboration will use synergies between the modular multispecific immunotherapies from CDR-Life and the pharmacoscopy technology from the Snijder laboratory to explore both the biology that drives immune cell engagement and the principles that guide optimal drug design.

“CDR-Life’s multispecific molecules are ideal together with our pharmacoscopy technology to deduce impactful learnings about the biology of immune cell engagement” said Prof. Snijder.

“Pharmacoscopy has been shown to be highly predictive of clinical outcome,” said Dr. Christian Leisner, chief executive officer of CDR-Life. “This is contrary to many in vitro and in vivo methods and makes it a powerful tool to understand the impact of our trispecific immunotherapies.”

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CDR-Life Announces Formation of Scientific Advisory Board

Inaugural Members Include Leading Ophthalmic Luminaries from the United States and Europe.

ZURICH, Switzerland, May 8, 2017 – CDR-Life Inc., a biotechnology company focused on advancing therapeutic antibody fragments in the areas of ophthalmology and oncology, today announced the formation of a Scientific Advisory Board (SAB) comprised of academic and industry experts in the field of ophthalmology from both the United States and Europe.

The Scientific Advisory Board will serve as a vital strategic resource to the Company to develop novel treatments for ophthalmic diseases. In addition to guiding CDR-Life’s research and development activities, including clinical trial designs, the SAB will also identify new target indications and will evaluate strategic assets that leverage the management’s expertise in therapeutic antibody fragments.

“We are pleased to welcome this diverse group of ophthalmic experts, representing thought leaders from clinical practice and academia, to our newly formed Scientific Advisory Board,” said Dominik Escher, PhD, executive chairman of CDR-Life. “The expertise that they bring to our executive team and Board will prove invaluable as we refine our clinical plan and work to bring novel therapies to patients in need.”

“We believe our approach to developing novel therapeutic antibody fragments holds significant potential in ophthalmology and oncology where unmet medical needs persist,” said Christian Leisner, PhD, chief executive officer of CDR-Life. “We look forward to leveraging the varied experience of our new Scientific Advisory Board as we pursue the efficient development of our proprietary molecules.”

The Advisory Board members include:

Reza Dana, MDDirector at Harvard Medical School, Department of Ophthalmology, Cornea Center of Excellence

Pravin Dugel, MDManaging Partner, Retinal Consultants of Arizona (RCA)

Frank G. Holz, MDChairman and Professor at the Department of Ophthalmology, University of Bonn

Stephan Michels, MDProfessor at the University of Zurich and Vice Chair at City Hospital Triemli, Zurich, Switzerland

Manfred Zierhut, MDProfessor at University Hospital of Tuebingen, Germany

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